Tenuazonic acid production by Alternaria alternata and Alternaria tenuissima isolated from cotton

N. D. Davis, U. L. Diener, G. Morgan‐Jones
1977-08-01

Alternaria alternataAlternaria tenuissimaTenuazonic acidbrine shrimp and chicken embryo bioassayscottonseed production
Cultures of Alternaria alternata (three isolates) and Alternaria tenuissima (three isolates) obtained from cottonseeds and bolls were toxigenic when cultured on various laboratory media. A mycotoxin was isolated and identified as tenuazonic acid by using solvent partition, thin-layer chromatography, and instrument analyses. Toxicity was monitored with brine shrimp and chicken embryo bioassays. All cultures except A. alternata 938 produced tenuazonic acid when grown on cottonseed and on yeast extract-sucrose broth. The most toxin (266 mg/kg) was produced by A. tenuissima 843 on cottonseed.
1
A mycotoxin produced by these isolates was isolated and identified as tenuazonic acid using solvent partition, thin-layer chromatography, and instrument analyses.
2
All cultures except A. alternata 938 produced tenuazonic acid when grown on cottonseed and on yeast extract-sucrose broth.
3
Alternaria alternata (3 isolates) and Alternaria tenuissima (3 isolates) obtained from cottonseeds and bolls are toxigenic on various laboratory media.
4
The highest tenuazonic acid yield observed was 266 mg/kg produced by A. tenuissima 843 on cottonseed.
5
Toxicity of culture extracts was confirmed by brine shrimp and chicken embryo bioassays.

Cultures of Alternaria alternata and Alternaria tenuissima isolates obtained from cottonseeds and bolls

Production of the mycotoxin tenuazonic acid by these Alternaria isolates on various media (including cottonseed and yeast extract–sucrose broth) and its toxicity as measured by bioassays

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1977-08-01
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N. D. Davis
U. L. Diener
G. Morgan‐Jones
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