HEART DISEASE IN CHILDREN WITH RESPIRATORY INFECTIONS
Заболевания сердца у детей с респираторными инфекциями
2016-01-01
SCID: 54.1/3ah6kmfe
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ECG dispersion mappingcardiac pathologymixed infectionsmyocarditispediatric respiratory infections
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Abstract (AI)
The link between heart disease and infectious pathogens is well known. Despite the high frequency of cardiac pathology in infectious diseases, it is rarely diagnosed because of lack of specific clinical and laboratory symptoms. It is especially difficult to diagnose in children. Airborne infections in the structure of infectious morbidity of children occupy a leading place. The aim of this work was to study the nature of the lesions of the heart in children suffering from acute infection of the respiratory tract. Materials and methods: 341 children with acute respiratory infection of moderate severity were surveyed by a method of ECG dispersion mapping. Cardiac pathology has not previously been determined in these children. Signs of disease of the heart was identified in 76 children (22%). Further study included instrumental (ECG, ECHO-KG, daily monitoring of ECG), biochemical and etiological (ELISA, PCR, immunocytochemical) research methods for determining the nature of the damage to the heart and the etiology of the disease. Results. Myocarditis was diagnosed in 2% of children, a violation of repolarization – in 21%, heart rhythm disorders – in 35% (AV – blockade in 4%). Most often signs of heart disease were detected in children with Epstein-Barr virus (32%), streptococcal (28%), cytomegalovirus (25%), herpesvirus type 6 infection (24%). Pathogens from the group of acute respiratory virus infections were identified in 28%, enterovirus – in 10%, Haemophilus influenzae – in 10%, Mycoplasma pneumonia – in 10%, Pneumococcus – in 9%, Chlamydia – in 9%, Parvovirus B19 – in 6%. Conclusion. Sensitive screening test to detect cardiac pathology is the method of ECG dispersion mapping. Heart damage in children with respiratory diseases in 60% of cases is associated with mixed infections. Timely diagnosis of lesions of the heart in infectious diseases in children allows to adjust the therapy in the early stages and prevent the development of chronic pathology of the heart.
Key Findings
1
Among 341 children with moderate acute respiratory infections, previously unrecognized cardiac abnormalities were detected in 76 children (22%) using ECG dispersion mapping.
2
Cardiac abnormalities were most frequently associated with Epstein-Barr virus (32%), streptococcal infection (28%), cytomegalovirus (25%), and human herpesvirus type 6 (24%).
3
ECG dispersion mapping was identified as a sensitive screening method for detecting cardiac pathology and may support early treatment adjustment to prevent chronic cardiac disease.
4
Mixed infections accounted for 60% of cases involving heart damage in children with respiratory diseases.
5
The identified cardiac manifestations included myocarditis in 2% of children, repolarization abnormalities in 21%, and heart rhythm disorders in 35%, including atrioventricular block in 4%.
Research Object
Children with acute respiratory infections of moderate severity
Research Subject
The nature and types of cardiac damage, including myocarditis, repolarization abnormalities, and heart rhythm disorders, and their association with infectious pathogens
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2016-01-01
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