Ceria Nanoparticles that can Protect against Ischemic Stroke
Наночастицы диоксида церия, способные защищать от ишемического инсульта
2012-09-11
SCID: 54.1/3c37naj9
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apoptosisceria nanoparticlesinfarct volumeischemic strokereactive oxygen species
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Abstract (AI)
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
Key Findings
1
At optimal doses, ceria nanoparticles reduce infarct volume and ischemic cell death in vivo.
2
PEGylated ceria nanoparticles protect cells from ROS-induced death in vitro.
3
Uniform 3 nm ceria nanoparticles protect against ischemic stroke by scavenging reactive oxygen species and reducing apoptosis.
Research Object
3 nm-sized PEGylated ceria nanoparticles in ischemic stroke models
Research Subject
Neuroprotective effects through reactive oxygen species scavenging, reduced apoptosis, and decreased infarct volume and ischemic cell death
Publication Details
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2012-09-11
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