Twenty-seven-year time trends in dementia incidence in Europe and the United States
Двадцатисемилетние временные тенденции заболеваемости деменцией в Европе и Соединённых Штатах
2020-07-01
SCID: 54.1/3ghf3afq
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Alzheimer Cohort ConsortiumEurope and North Americadementia incidencepopulation-based cohort studiestime trends
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Abstract (AI)
OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
Key Findings
1
Across seven population-based cohorts in Europe and the United States, dementia incidence declined by 13% per calendar decade from 1988 to 2015.
2
Dementia incidence increased sharply with age, from about 4 per 1,000 person-years at ages 65–69 to 65 per 1,000 person-years at ages 85–89.
3
Incidence rates were similar for women and men, but the decline was more pronounced in men: 24% versus 8% per decade, respectively.
4
The decline was consistent across studies, supporting a broad temporal reduction in dementia incidence over approximately 25 years.
5
The findings highlight the need to identify causes of the decline and assess whether it applies across geographically and ethnically diverse populations.
Research Object
All-cause dementia in individuals over 65 years of age in population-based cohorts from Europe and the United States (1988–2015)
Research Subject
Twenty-seven-year temporal trends in dementia incidence, including age- and sex-specific patterns and differences between men and women
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2020-07-01
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