Tracking Polymicrobial Metabolism in Cystic Fibrosis Airways: Pseudomonas aeruginosa Metabolism and Physiology Are Influenced by Rothia mucilaginosa-Derived Metabolites

Отслеживание полимикробного метаболизма в дыхательных путях при муковисцидозе: метаболизм и физиология Pseudomonas aeruginosa под влиянием метаболитов, производимых Rothia mucilaginosa
Oliver Fiehn, Katrine Whiteson, Bei Gao, Ying Zhang, Tara Gallagher, Mona Elbadawi-Sidhu, Zijuan Lai
2018-04-24

Pseudomonas aeruginosa metabolismRothia mucilaginosa-derived metabolitescystic fibrosis airwaysmicrobe-microbe metabolic interactionspolymicrobial metabolism
Pseudomonas aeruginosa is a dominant and persistent cystic fibrosis pathogen. Although P. aeruginosa is accompanied by other microbes in the airways of cystic fibrosis patients, few cystic fibrosis studies show how P. aeruginosa is affected by the metabolism of other bacteria. Here, we demonstrate that P. aeruginosa generates primary metabolites using substrates produced by another microbe that is prevalent in the airways of cystic fibrosis patients, Rothia mucilaginosa . These results indicate that P. aeruginosa may get a metabolic boost from its microbial neighbor, which might contribute to its pathogenesis in the airways of cystic fibrosis patients.
1
Metabolites from Rothia mucilaginosa can provide a metabolic boost to Pseudomonas aeruginosa
2
Pseudomonas aeruginosa metabolism and physiology are influenced by metabolites produced by Rothia mucilaginosa
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This metabolic interaction may contribute to Pseudomonas aeruginosa pathogenesis in cystic fibrosis airways

Pseudomonas aeruginosa in cystic fibrosis airways interacting with metabolites from Rothia mucilaginosa

Effects of Rothia mucilaginosa-derived metabolites on Pseudomonas aeruginosa metabolism and physiology (polymicrobial metabolic interactions relevant to CF airway pathogenesis)

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2018-04-24
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Oliver Fiehn
Katrine Whiteson
Bei Gao
Ying Zhang
Tara Gallagher
Mona Elbadawi-Sidhu
Zijuan Lai
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