An In Vivo Study to Compare and Evaluate the Antimicrobial Efficacy and pH Change of GC Tooth Mousse and CurodontTM Protect against Streptococcus mutans

Original research fluoride alone. [2][3]3][4][5][6] Various other remineralizing agents are also available, including xylitol, grape seed extract, ozone, SDF, etc.Curodont TM Protect is a newer remineralizing agent recently introduced, which comprises fluoride varnish, bioactive glass, and CPP-ACPF.It has oligopeptide 103 technology incorporated as a biomimetic matrix enriched with calcium, phosphate, and fluoride.It has various clinical benefits, especially in patients with IntroductIonDental caries is the most prevalent oral healthcare problem worldwide, especially in pediatric patients. 1Dental decay is caused by a major component of the human diet, i.e., sucrose, which is consumed by a microbacterium named Streptococcus mutans.It emerges as the most chief bacteria, which was isolated from a carious tooth.As per the reports of an article in Eastern Mediterranean Health Journal, children aged 6-15 years had a 66% prevalence of caries.When the tooth develops caries, it undergoes demineralization, which leads to the weakening of the tooth structure. 2,3There are mainly two types of remineralizing agents: fluoridated and nonfluoridated. 4Fluoride has been used as a remineralizing agent for decades; however, its use has become limited due to toxicity issues.Some nonfluoride remineralizing agents present in the market are, for example, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP; GC Tooth Mousse) with CPPs obtained from tryptic digestion of milk phosphoprotein, i.e., casein.This protein stabilizes the calcium and phosphate ions, leading to the formation of a complex named CPP-ACP.Other fluoridated agents available are CPP-ACPF (e.g., Tooth Mousse plus).Reynolds et al. experimented on this technology and stated that when 2% CPP-ACP with 1,100 ppm fluoride was provided in a dentifrice together, it had far more fluoride incorporation than 1,2,4-