A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Michel Rodrigo Zambrano Passarini, Célio Lopes Silva, Aline Maria de Vita-Marques, Simone Possedente de Lira, Roberto G. S. Berlinck, Mirna Helena Regali Seleghim, Sandra Regina Pombeiro Sponchiado, Sâmia Maria Tauk-Tornisielo, Margarida Barata, Cláudia Pessoa, Manoel Odorico de Moraes, Bruno Coêlho Cavalcanti, Gislene G. F. Nascimento, Ana Olı́via de Souza, Fábio C. S. Galetti, Márcio Silva, Eli F. Pimenta, Otávio Henrique Thiemann, Lara Durães Sette

2008-01-01

SCID: 54.1/4gzbwgym

Abstract (AI)

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.

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DOI

10.1590/s0100-40422008000500030

Publication Date

2008-01-01

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Authors

Michel Rodrigo Zambrano Passarini

Célio Lopes Silva

Aline Maria de Vita-Marques

Simone Possedente de Lira

Roberto G. S. Berlinck

Mirna Helena Regali Seleghim

Sandra Regina Pombeiro Sponchiado

Sâmia Maria Tauk-Tornisielo

Margarida Barata

Cláudia Pessoa

Manoel Odorico de Moraes

Bruno Coêlho Cavalcanti

Gislene G. F. Nascimento

Ana Olı́via de Souza

Fábio C. S. Galetti

Márcio Silva

Eli F. Pimenta

Otávio Henrique Thiemann

Lara Durães Sette

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