A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Многоэтапный скрининг метаболитов морских грибов и выделение циклодепсипептидов из Beauveria felina
Michel Rodrigo Zambrano Passarini, Célio Lopes Silva, Aline Maria de Vita-Marques, Simone Possedente de Lira, Roberto G. S. Berlinck, Mirna Helena Regali Seleghim, Sandra Regina Pombeiro Sponchiado, Sâmia Maria Tauk-Tornisielo, Margarida Barata, Cláudia Pessoa, Manoel Odorico de Moraes, Bruno Coêlho Cavalcanti, Gislene G. F. Nascimento, Ana Olı́via de Souza, Fábio C. S. Galetti, Márcio Silva, Eli F. Pimenta, Otávio Henrique Thiemann, Lara Durães Sette
2008-01-01

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
1
Analysis of extracts from 57 marine-derived fungal strains by HPLC-PDA, TLC and ¹H NMR revealed that growth conditions affect crude extract chemical profiles.
2
Chemical investigation of antimycobacterial and cytotoxic crude extracts from two Beauveria felina strains yielded cyclodepsipeptides related to destruxins.
3
Most fungal strains producing bioactive or chemically distinctive crude extracts were isolated from sediments or marine algae.
4
The multi-screening approach is a valuable tool for selecting fungal strains that produce chemically interesting or biologically active secondary metabolites.
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2008-01-01
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Authors
Michel Rodrigo Zambrano Passarini
Célio Lopes Silva
Aline Maria de Vita-Marques
Simone Possedente de Lira
Roberto G. S. Berlinck
Mirna Helena Regali Seleghim
Sandra Regina Pombeiro Sponchiado
Sâmia Maria Tauk-Tornisielo
Margarida Barata
Cláudia Pessoa
Manoel Odorico de Moraes
Bruno Coêlho Cavalcanti
Gislene G. F. Nascimento
Ana Olı́via de Souza
Fábio C. S. Galetti
Márcio Silva
Eli F. Pimenta
Otávio Henrique Thiemann
Lara Durães Sette
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