Relationship Between IL-10 Single Nucleotide Polymorphisms (rs1800871, rs1800872, and rs1800896) and the Severity of COVID-19

Hossein Azadinejad, Parisa Feizollahi, Alireza Rezaeimanesh, Farhad Salari, Ali Gorgin Karaji
2024-09-10
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COVID-19 severityIL-10 single nucleotide polymorphismsrs1800871 (−819 A>G)rs1800872 (−592 T>G)rs1800896 (−1082 C>T)
Abstract (AI)
Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose levels are elevated in patients with severe COVID-19. IL-10 polymorphisms may play a role in increasing IL-10 levels and the severity of COVID-19. This study aimed to investigate the relationship between IL-10 single nucleotide polymorphisms (SNPs) (rs1800896 [−1082 C < T], rs1800871 [−819 A > G], and rs1800872 [−592 T > G]) and the severity of COVID-19 in patients from Kermanshah Province, Iran.
Key Findings
1
No significant association was found between IL-10 SNP rs1800871 (-819 A>G) genotypes and COVID-19 severity (p > 0.05).
2
No significant association was found between IL-10 SNP rs1800872 (-592 T>G) genotypes and COVID-19 severity (p > 0.05).
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No significant association was found between IL-10 SNP rs1800896 (-1082 C>T) genotypes and COVID-19 severity (p > 0.05).
4
Study involved 150 mild and 143 severe COVID-19 patients from Kermanshah Province, Iran, with genotypes determined by PCR-RFLP.
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2024-09-10
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Authors
Hossein Azadinejad
Parisa Feizollahi
Alireza Rezaeimanesh
Farhad Salari
Ali Gorgin Karaji
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