Insights into mammalian TE diversity through the curation of 248 genome assemblies
Новые представления о разнообразии транспонируемых элементов у млекопитающих на основе аннотирования 248 сборок геномов
2023-04-27
SCID: 54.1/634k3rkv
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DNA transposon invasionsde novo TE curationlong interspersed elementsplacental mammal genomestransposable elements
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Abstract (AI)
We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE accumulation. This includes multiple recent expansion and quiescence events across the mammalian tree. Young TEs, particularly long interspersed elements, drive increases in genome size, whereas DNA transposons are associated with smaller genomes. Mammals tend to accumulate only a few types of TEs at any given time, with one TE type dominating. We also found association between dietary habit and the presence of DNA transposon invasions. These detailed annotations will serve as a benchmark for future comparative TE analyses among placental mammals.
Key Findings
1
Mammals generally resemble one another in total TE content and diversity, but differ substantially in recent TE accumulation, including repeated expansion and quiescence events.
2
Mammals typically accumulate only a few TE types at a time, with one type becoming dominant.
3
The presence of DNA transposon invasions is associated with dietary habits, and the annotations provide a benchmark for comparative TE analyses in placental mammals.
4
The study performed the largest de novo transposable-element curation effort in eukaryotes, analyzing 248 placental mammal genome assemblies.
5
Young TEs, especially long interspersed elements, contribute to genome-size increases, whereas DNA transposons are associated with smaller genomes.
Research Object
Transposable element content and dynamics in 248 placental mammal genome assemblies
Research Subject
Comparative patterns of recent TE accumulation, expansion and quiescence, including their relationships with genome size and dietary habit
Publication Details
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2023-04-27
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