Malignancy Associated with Low-Risk HPV6 and HPV11: A Systematic Review and Implications for Cancer Prevention
Злокачественные опухоли, связанные с низкорисковыми типами HPV6 и HPV11: систематический обзор и последствия для профилактики рака
2023-08-11
SCID: 54.1/6sjthbt5
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E7 geneHPV11HPV16HPV6laryngeal cancerlow-risk human papillomavirusmalignancypenile cancersingle and dual HPV6/11 infectionssystematic reviewvaccination strategies
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Abstract (AI)
gene, indicating a limited ability to block cell differentiation. The presence of single or dual HPV6/11 infections in variable proportions of penile and laryngeal cancers support the vaccination strategies that cover these genotypes, not only for preventing genital warts but also for cancer prevention. Other risk factors and co-carcinogens are likely to participate in epithelial carcinogenesis associated with low-risk HPV.
Key Findings
1
Genomic comparison shows HPV6/11 share similarities with high-risk HPV16 mainly in the E7 gene, suggesting a limited ability to block cell differentiation.
2
No HPV6/11 infections were detected in vulvar, vaginal, and oral cancers in the reviewed literature.
3
Presence of HPV6/11 in some penile and laryngeal cancers supports vaccination strategies covering these genotypes for cancer prevention, beyond genital wart prevention.
4
Single or dual HPV6/11 infections were found in 0–87.5% of laryngeal cancers across selected studies.
5
Systematic review of studies from the last 10 years found single or dual HPV6/11 infections in 0–5.5% of penile cancers.
Research Object
Low-risk human papillomavirus genotypes HPV6 and HPV11 in cancers (penile and laryngeal and other non-cervical sites)
Research Subject
Proportion and genomic characteristics of single and dual HPV6/11 infections in non-cervical cancers and their potential role in malignant transformation (comparative genomics versus high-risk HPV16) with implications for vaccination-based cancer prevention
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2023-08-11
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