Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis
Влияние клопидогрела, аспирина и комбинированной терапии в порочном ex vivo модели тромбоза стента, вызванного высоким сдвигом скорости
1998-10-01
SCID: 54.1/6vdjb4mb
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aspirinclopidogrelcombined therapyhigh-shear induced thrombosisporcine ex vivo modelstent thrombosisticlopidine
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Abstract (AI)
Aims Use of ticlopidine in coronary stenting is limited by delayed onset of action. We studied the effects of clopidogrel, a rapidly acting analog of ticlopidine alone, and in combination with aspirin, in inhibiting stent thrombosis.
Key Findings
1
Clopidogrel, a rapidly acting analog of ticlopidine, was studied for its effects in inhibiting stent thrombosis in a porcine ex vivo high-shear model.
2
The study evaluated clopidogrel alone and in combination with aspirin to determine their inhibitory effects on stent thrombosis.
3
The work addresses the clinical limitation of ticlopidine’s delayed onset by testing a faster-acting alternative (clopidogrel).
Research Object
Porcine ex vivo model of high-shear induced stent thrombosis
Research Subject
Effects of clopidogrel, aspirin, and their combined therapy on inhibition of stent thrombosis under high-shear conditions
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1998-10-01
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