Transcription infidelity and genome integrity: the parallax view

Christophe Herman, Priya Sivaramakrishnan, Jennifer A. Halliday, Alasdair J.E. Gordon
2018-06-22

It was recently shown that removal of GreA, a transcription fidelity factor, enhances DNA break repair. This counterintuitive result, arising from unresolved backtracked RNA polymerase impeding DNA resection and thereby facilitating RecA-loading, leads to an interesting corollary: error-free full-length transcripts and broken chromosomes. Therefore, transcription fidelity may compromise genomic integrity.
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2018-06-22
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Christophe Herman
Priya Sivaramakrishnan
Jennifer A. Halliday
Alasdair J.E. Gordon
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