Wnt pathway antagonistsWnt signalingcancer stem cellscolorectal cancertumor metastasis
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Abstract (AI)
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
Key Findings
1
Aberrant Wnt signaling occurs across numerous additional cancer entities, affecting both solid and liquid tumors.
2
Strategies targeting Wnt signaling are being developed, but therapeutic approaches face significant challenges.
3
The review summarizes newly identified Wnt pathway components and their effects on cancer development.
4
Wnt pathway activity contributes to cancer stem-cell maintenance, metastasis, and immune control.
5
Wnt signaling regulates development and stemness and is tightly associated with carcinogenesis, most prominently in colorectal cancer.
Research Object
Wnt signaling in cancer
Research Subject
The roles and mechanisms of Wnt signaling in cancer development, cancer stem cell maintenance, metastasis, immune control, and therapeutic targeting
Publication Details
Publication Date
2016-09-12
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