The importance of studying genetic polymorphism of TNFα -308 G/A in Helicobacter pylori infection

Background . Reactions caused by cytokine production are of particular importance in the development of inflammation in H. pylori infection. The gene polymorphisms determine the corresponding protein production level, which affects the outcomes of inflammatory processes. In H. pyloriassociated gastritis, proinflammatory cytokines predominate. In the work were the TNFα gene polymorphisms analyzed. The aim is to study the effect of TNFα -308 G/A (rs1800629) gene polymorphisms on the clinical features of H.pylori infection in a large industrial center of Russia. Materials and methods. TNFα gene polymorphisms in patients with different forms of H. pylori infection were determined by allele-specific PCR. Results. It was found that the risk of H. pylori associated diseases is higher in carriers of the GG TNFα – 308 G/A genotype. This genotype is characteristic of patients with erosive and ulcerative processes in the mucous membrane of stomach and duodenum. The risk of developing atrophic gastritis when infected with H. pylori is associated with the A allele and the GA genotype. Conclusions. The study of the TNFα -308 G/A genetic polymorphisms makes it possible to identify individuals with a high risk of H. pylori infection, the occurrence of destructive diseases of stomach and duodenum, and those at risk of developing precancerous mucosal changes in the form of atrophic H. pylori-associated gastritis in order to provide timely prevention and treatment.