Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India

Surjit Singh; Shigeaki Nonoyama; Kohsuke Imai; Osamu Ohara; Deepti Suri; Amit Rawat; Pamela Lee; YL Lau; Amita Aggarwal; Ankur Kumar Jindal; Pandiarajan Vignesh; Kanika Arora; Ranjana W. Minz; Manas Kalra; Anju Gupta; Biman Saikia; Aaqib Zaffar Banday; Rahul Tyagi; Vibhu Joshi; Sanjib Mondal; Jitendra Shandilya; Madhubala Sharma; Mukesh Desai; Prasad Taur; Ambreen Pandrowala; Vijaya Gowri; Sneha Sawant-Desai; Maya Gupta; Aparna Dalvi; Manisha Madkaikar; Revathi Raj; Ramya Uppuluri; Sagar Bhattad; Ananthvikas Jayaram; Harsha Prasada Lashkari; Liza Rajasekhar; Deenadayalan Munirathnam; Anuj Shukla; Ruchi Saka; Rajni Sharma; Ravinder Garg; Koon Wing Chan

doi:10.3389/fimmu.2020.612323

Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India

Клинический и генетический профиль X-сцепленной агаммаглобулинемии: многоклинический опыт из Индии

Surjit Singh, Shigeaki Nonoyama, Kohsuke Imai, Osamu Ohara, Deepti Suri, Amit Rawat, Pamela Lee, YL Lau, Amita Aggarwal, Ankur Kumar Jindal, Pandiarajan Vignesh, Kanika Arora, Ranjana W. Minz, Manas Kalra, Anju Gupta, Biman Saikia, Aaqib Zaffar Banday, Rahul Tyagi, Vibhu Joshi, Sanjib Mondal, Jitendra Shandilya, Madhubala Sharma, Mukesh Desai, Prasad Taur, Ambreen Pandrowala, Vijaya Gowri, Sneha Sawant-Desai, Maya Gupta, Aparna Dalvi, Manisha Madkaikar, Revathi Raj, Ramya Uppuluri, Sagar Bhattad, Ananthvikas Jayaram, Harsha Prasada Lashkari, Liza Rajasekhar, Deenadayalan Munirathnam, Anuj Shukla, Ruchi Saka, Rajni Sharma, Ravinder Garg, Koon Wing Chan

2021-01-15

SCID: 54.1/9x6ar5hp Discuss with AI

IndiaX-Linked Agammaglobulinemiaclinical profilediagnostic delaygenetic profileimmunoglobulin replacementmolecular diagnosismulticenter study

Abstract (AI)

There was a significant delay in the diagnosis and facilities for molecular diagnosis were not available at many centers. Optimal immunoglobulin replacement is still a challenge.

Key Findings

Molecular diagnostic facilities for X-linked agammaglobulinemia are unavailable at many centers in India.

Providing optimal immunoglobulin replacement therapy for X-linked agammaglobulinemia remains a challenge in this setting.

There is a significant delay in diagnosis of X-linked agammaglobulinemia among the multicenter cohort in India.

Research Object

X-linked agammaglobulinemia patients in India (multicenter cohort)

Research Subject

Clinical and genetic profile including diagnostic delays and availability of molecular diagnosis and challenges in optimal immunoglobulin replacement

Publication Details

DOI

10.3389/fimmu.2020.612323

Publication Date

2021-01-15

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https://www.frontiersin.org/articles/10.3389/fi…

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Author Information

Authors

Surjit Singh

Shigeaki Nonoyama

Kohsuke Imai

Osamu Ohara

Deepti Suri

Amit Rawat

Pamela Lee

YL Lau

Amita Aggarwal

Ankur Kumar Jindal

Pandiarajan Vignesh

Kanika Arora

Ranjana W. Minz

Manas Kalra

Anju Gupta

Biman Saikia

Aaqib Zaffar Banday

Rahul Tyagi

Vibhu Joshi

Sanjib Mondal

Jitendra Shandilya

Madhubala Sharma

Mukesh Desai

Prasad Taur

Ambreen Pandrowala

Vijaya Gowri

Sneha Sawant-Desai

Maya Gupta

Aparna Dalvi

Manisha Madkaikar

Revathi Raj

Ramya Uppuluri

Sagar Bhattad

Ananthvikas Jayaram

Harsha Prasada Lashkari

Liza Rajasekhar

Deenadayalan Munirathnam

Anuj Shukla

Ruchi Saka

Rajni Sharma

Ravinder Garg

Koon Wing Chan

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