Pharmacokinetic studies of a new substance of the water-soluble sulfur-containing antioxidant рotassium 3-(4-hydroxy-3,5-dimethylbenzylthio)propionate (TF-7)

Introduction. Pharmacokinetic (screening) studies are particularly relevant for the development of new substances and drugs. These studies investigate the basic processes such as absorption, distribution, metabolism and elimination (ADME) of a pharmaceutical substance. Pharmacokinetic parameters are of key importance to clinicians, as they provide data necessary for determining optimal dosages. Aim. To study the pharmacokinetic characteristics of a new substance of the water-soluble sulfur-containing antioxidant potassium 3-(4-hydroxy-3,5-dimethylbenzylthio)propionate (TF-7). Materials and methods. A TF-7 solution was administered to rats intragastrically at a dose of 500 mg/kg. Blood samples were collected 1,5, 3, 5, 8, and 12 h after administration of the substance. The TF-7 concentration was measured using stripping voltammetry. Calculations of pharmacokinetic parameters were performed using the single-compartment pharmacokinetic model – by the classical method according to Kholodov and using the Borgia 1.03 program. Results. The main pharmacokinetic parameters of the new TF-7 substance were calculated including half-life (t1/2), elimination rate constant (kel), total clearance (Clt), effective concentration (Ceff), and volume of distribution (Vd). Conclusion. The study showed rapid (t1/2) and effective distribution (Ceff, Vd) of TF-7 in the body, which ensures its ability to interact with all cellular and tissue structures. The half-life of TF-7 ranges from 1 to 1,5 h, indicating both a rapid onset of pharmacological effect and quite rapid elimination from the body.