Chromosomal Autoradiography in the Cri du Chat Syndrome
Авторентгенография хромосом при синдроме кошачьего крика
1964-01-01
SCID: 54.1/bcbmj9v8
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DNA synthesischromosomal autoradiographychromosome 5cri du chat syndromelate replication
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Abstract (AI)
The pattern of DNA synthesis in the chromosomes of Group 4–5 has been analysed in cells from individuals with the cri du chat syndrome. The abnormal chromosome, a No. 5, is one of the pair characterized by relatively early completion of synthesis in the long arms. The two remaining members of this group, characterized by extensive late replication throughout their lengths, therefore may now be recognized as the Nos. 4.
Key Findings
1
Chromosomal autoradiography analyzed DNA synthesis patterns in Group 4–5 chromosomes from individuals with cri du chat syndrome.
2
Replication-timing patterns provide a basis for distinguishing chromosomes 4 and 5 in cells affected by cri du chat syndrome.
3
The abnormal chromosome 5 associated with cri du chat syndrome shows relatively early completion of DNA synthesis in its long arms.
4
The two remaining Group 4–5 chromosomes exhibit extensive late replication along their lengths and can therefore be identified as chromosome 4.
Research Object
Chromosomes of Group 4–5 in cells from individuals with cri du chat syndrome
Research Subject
DNA synthesis and replication-timing patterns, including early completion in the long arms of the abnormal chromosome No. 5 and extensive late replication in chromosomes No. 4
Publication Details
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1964-01-01
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