Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Эволюционная история и глобальное распространение линии Beijing Mycobacterium tuberculosis
2015-01-19
SCID: 54.1/bwyyst68
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Mycobacterium tuberculosis Beijing lineagemultidrug-resistant tuberculosisphylogeographic reconstructionpositive selection mutationswhole-genome sequencing
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Abstract (AI)
Thierry Wirth, Philip Supply, Stefan Niemann and colleagues analyze 4,987 Mycobacterium tuberculosis strains of the Beijing lineage isolated from 99 countries. They report whole-genome sequencing of 110 representative strains, characterize global population structure and reconstruct the evolutionary history of this lineage. Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
Key Findings
1
Its population size increased successively over the past 200 years, coinciding approximately with industrialization, World War I, and HIV epidemics.
2
Putatively positively selected mutations associated with virulence may have contributed to expansion of the lineage’s most successful branches.
3
The Beijing lineage was analyzed using 4,987 isolates from 99 countries and whole-genome sequences from 110 representative strains.
4
The lineage originated in the Far East and subsequently spread worldwide through several radiation waves.
5
Two multidrug-resistant Beijing clones spread across Central Asia and Russia alongside the collapse of the former Soviet Union’s public health system.
Research Object
Mycobacterium tuberculosis Beijing lineage strains and their global populations
Research Subject
The biogeographical structure, evolutionary history, worldwide spread, population expansion, and emergence of MDR clones of the Beijing lineage
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2015-01-19
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