A framework for advancing our understanding of cancer-associated fibroblasts
Концептуальная основа для углубления понимания фибробластов, ассоциированных с опухолью
2020-01-24
SCID: 54.1/c9frtyck
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CAF heterogeneityCAF-targeted therapycancer-associated fibroblastsmatrix remodellingtumour microenvironment
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Abstract (AI)
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.
Key Findings
1
CAFs represent potential therapeutic targets for improving cancer treatment because of their broad influence on tumour biology.
2
Cancer-associated fibroblasts are key tumour-microenvironment components that deposit and remodel extracellular matrix and engage in reciprocal signalling with cancer cells and infiltrating leukocytes.
3
Effective CAF-targeted strategies should preserve CAF functions that inhibit tumour growth rather than eliminate CAF activity indiscriminately.
4
The consensus statement establishes a framework for advancing understanding of CAF biology and guiding therapeutic development.
5
Therapeutic modulation of CAFs is complicated by limited knowledge of their cellular origins and substantial functional heterogeneity.
Research Object
cancer-associated fibroblasts (CAFs) within the tumour microenvironment
Research Subject
the origins, functional heterogeneity, matrix-remodelling functions, reciprocal signalling with cancer cells, crosstalk with infiltrating leukocytes, and therapeutic modulation of CAFs
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2020-01-24
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