The role of porphyrin chemistry in tumor imaging and photodynamic therapy
Роль химии порфиринов в визуализации опухолей и фотодинамической терапии
2010-08-09
SCID: 54.1/dn9hm7w9
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long-wavelength photosensitizersphotodynamic therapyporphyrin chemistrytheranosticstumor imaging
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Abstract (AI)
In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references).
Key Findings
1
Long-wavelength-absorbing photosensitizers offer important advantages for PDT and are a central focus of the review.
2
Porphyrin-based compounds can be engineered into conjugates combining tumor imaging and therapeutic functions, enabling theranostic applications.
3
Recent advances in developing improved PDT agents are critically examined, including synthetic strategies developed at Roswell Park Cancer Institute.
4
The review explains the fundamental principles of porphyrin-based photodynamic therapy for cancer treatment.
5
The review summarizes the clinical status of selected porphyrin-based photodynamic therapy agents.
Research Object
Porphyrin-based compounds and their conjugates used for tumor imaging and photodynamic therapy
Research Subject
Their chemical design and photophysical, imaging, therapeutic, and clinical properties, including the development of long-wavelength-absorbing photosensitizers for theranostic applications
Publication Details
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2010-08-09
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