Considerations in the search for epistasis
Соображения по поиску эпистаза
2024-11-19
SCID: 54.1/dpaak8ge
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additive heritability modelepistasisgenetic interactionsmissing heritabilitysingle nucleotide polymorphism
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Abstract (AI)
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to recover this missing heritability. We identify key challenges and propose that future works need to leverage idealized systems, known biology and even previously identified epistatic interactions, in order to guide the search for new interactions.
Key Findings
1
Despite its biological plausibility, the search for epistasis has largely failed to account for missing heritability.
2
Epistasis describes context-dependent genetic effects that could explain phenotypic variation beyond additive heritability models.
3
Future searches should be guided by idealized systems, established biological knowledge, and previously identified epistatic interactions.
4
Major challenges hinder the reliable detection of epistatic interactions in genetic studies.
Research Object
epistatic interactions among genetic units, including single nucleotide polymorphisms and genes
Research Subject
the challenges and guiding principles for searching for epistasis to explain missing heritability
Publication Details
Publication Date
2024-11-19
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