Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Совместное использование и коллективная курирование данных масс-спектрометрии с помощью Global Natural Products Social Molecular Networking
2016-08-01
SCID: 54.1/e4q863ag
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Global Natural Products Social Molecular NetworkingMS/MS spectral librariescrowdsourced curationliving datamass spectrometry
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Abstract (AI)
The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
Key Findings
1
Crowdsourced curation of community-wide reference MS libraries is designed to improve mass-spectral annotations.
2
Data-driven social networking in GNPS can facilitate spectrum identification and promote collaborations among researchers.
3
GNPS introduces “living data” through the continuous reanalysis of deposited mass-spectrometry datasets.
4
GNPS is introduced as an open-access knowledge base for organizing and sharing raw, processed, and identified MS/MS data on natural products.
5
The platform addresses the lack of searchable raw-data resources and limited data-sharing mechanisms in natural-products research.
Research Object
Global Natural Products Social Molecular Networking (GNPS) knowledge base for mass spectrometry data
Research Subject
Community-wide organization, sharing, crowdsourced curation, annotation, and continuous reanalysis of natural-products MS/MS data
Publication Details
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2016-08-01
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