Clinical Determinants of Longitudinal Disability in LGI-1-IgG Autoimmune Encephalitis

Клинические детерминанты долгосрочной инвалидности при аутоиммунном энцефалите с антителами к LGI-1 (LGI-1-IgG)
Vineet Punia, Jeffrey A. Cohen, Amy Kunchok, Rachel Galioto, Albert Aboseif, Yadi Li, Moein Amin, Brittany Lapin, Alex Milinovich, Justin Abbatemarco, Alex Rae-Grant
2023-11-10
SCID:  54.1/errceu9a Discuss with AI
12-month outcomesClinical Assessment Scale in Autoimmune Encephalitis (CASE)LGI-1-IgG autoimmune encephalitiscognitive impairmentlongitudinal disabilitymemory dysfunctionmodified Rankin Scale (mRS)psychiatric disturbancetemporal lobe T2 hyperintensity
Abstract (AI)
Overall, there was a high degree of correlation between mRS and CASE scores in patients with LGI-1-IgG AE, with both scores improving significantly after 12 months. Memory dysfunction and psychiatric disturbance were the most prevalent longitudinal symptoms. Cognitive impairment and temporal lobe T2 hyperintensity at baseline were both associated with greater disability at long-term follow-up, underscoring these as important determinants of disability outcomes in LGI-1-IgG AE.
Key Findings
1
Baseline cognitive impairment is associated with greater long-term disability.
2
Both mRS and CASE scores show significant improvement after 12 months.
3
Memory dysfunction and psychiatric disturbance are the most prevalent persistent longitudinal symptoms.
4
Modified Rankin Scale (mRS) and Clinical Assessment Scale in Autoimmune Encephalitis (CASE) scores are highly correlated in LGI-1-IgG autoimmune encephalitis patients.
5
Temporal lobe T2 hyperintensity at baseline is associated with greater long-term disability.
Research Object

Patients with LGI-1-IgG autoimmune encephalitis

Research Subject

Clinical determinants of longitudinal disability including baseline cognitive impairment and temporal lobe T2 hyperintensity and their association with long-term disability measured by mRS and CASE scores

Publication Details
Publication Date
2023-11-10
Journal
Publisher
ISSN
Cited by
27
Access Type
Author Information
Authors
Vineet Punia
Jeffrey A. Cohen
Amy Kunchok
Rachel Galioto
Albert Aboseif
Yadi Li
Moein Amin
Brittany Lapin
Alex Milinovich
Justin Abbatemarco
Alex Rae-Grant
Explore further
Open the scid.ai AI chat with a ready-made request: it will find papers on a similar topic and help build a literature review.
Find similar papers in the chat →
Make a presentation
100%