Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Гематоэнцефалический барьер: проблема эффективной терапии опухолей головного мозга
Arijit Bhowmik, Rajni Khan, Mrinal K. Ghosh
2015-01-01

blood-brain barrierbrain tumorsdrug delivery to the brainefflux transport systemstherapeutic strategies
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.
1
BBB-associated efflux machinery actively limits the accumulation of several therapeutic drugs in the brain.
2
Brain tumors have generally poor to fair prognoses and high relapse rates, increasing the need for improved treatment approaches.
3
Successful therapy requires modified drug-delivery methods and novel therapeutic strategies designed to overcome or bypass the BBB.
4
The blood-brain barrier is a major obstacle to effective brain tumor treatment because its molecular components and transport systems restrict drug entry.
5
The review examines BBB composition and function alongside effective brain drug-delivery approaches and barrier-overcoming therapeutic strategies.

the blood-brain barrier in the context of brain tumor treatment

its molecular composition, transport and efflux functions, and strategies for overcoming it to improve drug delivery and brain tumor therapy

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2015-01-01
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Authors
Arijit Bhowmik
Rajni Khan
Mrinal K. Ghosh
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