Phage therapy: From biological mechanisms to future directions
Фаговая терапия: от биологических механизмов к перспективным направлениям
2023-01-01
SCID: 54.1/fcbge2j9
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antimicrobial resistanceclinical applications of phagesgenetically modified phageslytic bacteriophagesphage therapy
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Abstract (AI)
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.
Key Findings
1
Current state of phage therapy spans biological mechanisms, clinical applications, challenges, and future directions including natural, genetically modified, and synthetic phages.
2
Developing therapeutic phages requires coordinated effort among multiple stakeholders.
3
Rising antimicrobial resistance has renewed interest in bacteriophage research as therapeutic agents.
4
Therapeutic phages should preferably be lytic, efficiently kill their bacterial host, and be fully characterized to exclude side effects.
Research Object
Therapeutic bacteriophages (naturally occurring, genetically modified, and synthetic phages)
Research Subject
Biological mechanisms, clinical applications, development challenges, characterization requirements, and future directions for using phages as antibacterial therapeutics
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2023-01-01
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