Adaptive plasticityAstrocytesCNS homeostasisCentral nervous systemNeural networks
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Abstract (AI)
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in morphological appearance; they express a multitude of receptors, channels, and membrane transporters. This complement underlies their remarkable adaptive plasticity that defines the functional maintenance of the CNS in development and aging. Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Key Findings
1
Astrocytes are ectodermal, neuroepithelial-derived neural cells that maintain central nervous system homeostasis and provide defense.
2
Astrocytes are tightly integrated into neural networks and regulate CNS homeostasis across molecular, cellular, tissue, and whole-organ levels.
3
Astrocytes exhibit substantial morphological heterogeneity and express diverse receptors, ion channels, and membrane transporters.
4
Their molecular complement enables adaptive plasticity supporting functional maintenance of the central nervous system during development and aging.
Research Object
astrocytes in the central nervous system
Research Subject
their heterogeneous morphology, molecular complement, adaptive plasticity, and roles in maintaining CNS homeostasis and defense across development and aging
Publication Details
Publication Date
2017-12-24
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