The brain after COVID-19: Compensatory neurogenesis or persistent neuroinflammation?
Мозг после COVID-19: компенсаторный нейрогенез или персистирующее нейровоспаление?
2020-12-24
SCID: 54.1/ga3byz4z
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COVID-19compensatory neurogenesisgrey matter volumeneuroinflammationwhite matter diffusion
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Abstract (AI)
Yiping Lu et al. [1] report increased grey matter volumes and changes in MRI-based measures of water diffusion in white matter in the brains of recovered COVID-19 patients three months after acute illness, compared to healthy controls. They propose that neurogenesis and hypertrophy caused volumetric enlargement, and pathway remyelination restricted diffusion in the patients. If valid, these explanations suggest vigorous and counter-intuitive compensatory brain mechanisms during recovery from COVID-19.
Key Findings
1
MRI revealed altered water-diffusion measures in white matter among recovered COVID-19 patients.
2
Recovered COVID-19 patients showed increased grey matter volumes three months after acute illness compared with healthy controls.
3
Restricted white-matter diffusion was proposed to reflect pathway remyelination during recovery.
4
The proposed compensatory explanations remain uncertain and contrast with the possibility of persistent neuroinflammation.
5
The reported findings were interpreted as possible neurogenesis and hypertrophy causing grey-matter enlargement.
Research Object
Brains of recovered COVID-19 patients three months after acute illness
Research Subject
Post-COVID-19 changes in grey-matter volume and white-matter water diffusion, and their possible mechanisms of compensatory neurogenesis, hypertrophy, and remyelination versus persistent neuroinflammation
Publication Details
Publication Date
2020-12-24
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