Apathy: Neurobiology, Assessment and Treatment
Апатия: нейробиология, оценка и лечение
2021-04-23
SCID: 54.1/h3cn5qqj
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apathyclinical assessmentgoal-directed activityneurobiologyneuropsychiatric disorders
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Abstract (AI)
Apathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of in multiple dimensions including behavior/cognition, emotion and social interaction. It has been described in major depressive disorder, Alzheimer's disease, frontotemporal dementia, Parkinson's Disease, cerebrovascular disease, and vascular dementia, among others. This review will address the neuropsychology and associated neurobiological underpinnings of apathy in the above conditions, identify specific methods to assess apathy clinically, and review the literature on managing apathy across these various disorders.
Key Findings
1
Apathy involves multiple dimensions, including behavior and cognition, emotion, and social interaction.
2
Apathy is a highly prevalent, disabling, and treatment-resistant syndrome characterized by reduced goal-directed activity relative to a patient’s prior level.
3
Apathy occurs across major depressive disorder, Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, cerebrovascular disease, and vascular dementia.
4
Clinical assessment methods and management strategies for apathy must be considered across its diverse neurological and psychiatric causes.
5
Understanding apathy requires integrating its neuropsychological features with associated neurobiological mechanisms across different disorders.
Research Object
Apathy syndrome across major depressive disorder, Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, cerebrovascular disease, and vascular dementia
Research Subject
The neuropsychological and neurobiological underpinnings, clinical assessment, and management of apathy
Publication Details
Publication Date
2021-04-23
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