Sudden gains in day-to-day change: Revealing nonlinear patterns of individual improvement in depression.

Резкие улучшения при ежедневных изменениях: выявление нелинейных паттернов индивидуального улучшения при депрессии
Marieke A. Helmich, Marieke Wichers, Merlijn Olthof, Guido Strunk, Benjamin Aas, Wolfgang Aichhorn, Günter Schiepek, Evelien Snippe
2020-01-02

daily self-rated problem severitydepression treatment responsedynamical systemsnonlinear change trajectoriessudden gains
OBJECTIVE: We examined individual overall trajectories of change and the occurrence of sudden gains in daily self-rated problem severity and the relation of these patterns to treatment response. METHOD: = 329, mean age = 44, 55% women) completed daily self-ratings about the severity of their complaints as a standard part of treatment, using the Therapy Process Questionnaire (TPQ). Per individual, the best-fitting defined (linear, log-linear, 1-step) trajectory was tested for significance: for change over time, and for specificity of the best-fitting trajectory. Two-hundred and three cases had ICD-10 Symptom Rating (ISR) depression scores posttreatment: a score ≤1 identified 114 treatment responders. Relation to response was examined for sudden gains and type of change trajectory. RESULTS: 138 cases (42%) had a significant decrease in problem severity, of which 54 cases (16%) had a defined trajectory: 50 cases with one-step improvement, and 4 with a linear improvement in daily problem severity. Sudden gains occurred in 28% of the total sample, and within 58% of improvement patterns. Specifically, sudden gains occurred in 68% of significant 1-step trajectories and 25% of the linear cases. Sudden gains and nonspecific change trajectories were significantly more frequent for treatment responders. CONCLUSIONS: At the day-level, patterns of improvement are nonlinear for most patients. Sudden gains occur within various forms of overall change and are associated with treatment response. Clinically relevant improvements in depression occur both gradually and abruptly, and this finding allows for the possibility that the remission process functions according to dynamical systems principles. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
1
Among 329 treated individuals, 42% showed a significant decrease in daily self-rated problem severity; only 16% had a statistically defined trajectory.
2
Most defined improvement trajectories were nonlinear: 50 involved one-step improvement, compared with only 4 showing linear improvement.
3
Sudden gains and nonspecific change trajectories were significantly more frequent among treatment responders, indicating that clinically relevant improvement can be gradual or abrupt.
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Sudden gains occurred in 28% of the total sample and in 58% of cases exhibiting significant improvement patterns.
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Sudden gains occurred in 68% of significant one-step trajectories and 25% of linear improvement trajectories.

Individual patients undergoing depression treatment, with daily self-rated problem severity

Nonlinear day-to-day improvement trajectories, sudden gains, and their associations with treatment response

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2020-01-02
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Marieke A. Helmich
Marieke Wichers
Merlijn Olthof
Guido Strunk
Benjamin Aas
Wolfgang Aichhorn
Günter Schiepek
Evelien Snippe
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