Antimicrobial photodynamic therapy: An overview

Антимикробная фотодинамическая терапия: обзор
Elizabeth Koshi, Sasidharan Rajesh, Koshi Philip, Aparna Mohan
2011-01-01

antimicrobial photodynamic therapydental plaque biofilmperiodontal diseaseperiopathogenic bacteriaphotosensitizer
Inflammatory periodontal disease caused by dental plaque is characterized by the clinical signs of inflammation and loss of periodontal tissue support. The mechanical removal of this biofilm and adjunctive use of antibacterial disinfectants and antibiotics have been the conventional methods of periodontal therapy. But the removal of plaque and the reduction in the number of infectious organisms can be impaired in sites with difficult access. The possibility of development of resistance to antibiotics by the target organism has led to the development of a new antimicrobial concept with fewer complications. Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug. PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteria.
1
Antibiotic resistance concerns have motivated development of antimicrobial approaches with fewer complications.
2
Antimicrobial photodynamic therapy uses a photosensitizer activated by an appropriately wavelength-matched low-power laser to kill microorganisms.
3
Mechanical plaque removal and antibacterial treatments may be less effective in periodontal sites that are difficult to access.
4
PDT may serve as an adjunct to mechanical treatment and antibiotics for eliminating periopathogenic bacteria.
5
Periodontal disease is driven by dental-plaque biofilms that cause inflammation and loss of periodontal tissue support.

periopathogenic bacteria in dental plaque associated with inflammatory periodontal disease

the antimicrobial efficacy and adjunctive therapeutic potential of photodynamic therapy using low-power lasers and photosensitizers

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Publication Date
2011-01-01
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Authors
Elizabeth Koshi
Sasidharan Rajesh
Koshi Philip
Aparna Mohan
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