Trisodium Citrate Dihydrate-Catalyzed One-Pot Three-component Synthesis of Biologically Relevant Diversely Substituted 2-Amino-3-Cyano-4-(3- Indolyl)-4H-Chromenes under Eco-Friendly Conditions
Катализируемый дигидратом тринатрия цитрата однофазный трехкомпонентный синтез биологически значимых разнообразно замещенных 2-амино-3-циано-4-(3-индолил)-4H-хроменов в экологичных условиях
2017-03-06
SCID: 54.1/n2z9t8rx
Discuss with AI
2-amino-3-cyano-4-(3-indolyl)-4H-chromenesTrisodium citrate dihydrategreen and sustainable chemistrymulticomponent reactionsone-pot three-component synthesis
Figures from the paper
Abstract (AI)
Background: Molecular hybridization (MH) is currently well-practiced in the rational drug design and has offered notable success in developing various lead candidates. With the proven pharmaceutical potentials of 4H-pyrans and indoles, the present work has been conceived to unit these two potent structural motifs within one molecular architecture by introducing a new protocol that satisfies several green chemistry aspects. Keywords: Multicomponent reactions, heterocycles, 2-amino-4-(indol-3-yl)-4H-chromene-3-carbonitriles, trisodium citrate dihydrate, aqueous ethanol, room temperature, green and sustainable chemistry.
Key Findings
1
A one-pot three-component synthesis protocol was developed for 2-amino-3-cyano-4-(3-indolyl)-4H-chromenes using trisodium citrate dihydrate as catalyst.
2
Reactions proceed under eco-friendly conditions: aqueous ethanol solvent and room temperature operation are used.
3
The method unites 4H-pyran and indole motifs into a single molecular architecture, supporting molecular hybridization for drug design.
4
The protocol emphasizes green and sustainable chemistry principles for preparing diversely substituted, biologically relevant chromene derivatives.
Research Object
Trisodium citrate dihydrate-catalyzed one-pot three-component synthesis of 2-amino-3-cyano-4-(3-indolyl)-4H-chromenes in aqueous ethanol at room temperature
Research Subject
Development and green-chemistry performance (reaction scope, diversity of substituents, catalytic efficiency using trisodium citrate dihydrate, and eco-friendly reaction conditions) for producing biologically relevant 2-amino-4-(indol-3-yl)-4H-chromene-3-carbonitriles
Publication Details
Publication Date
2017-03-06
Journal
Publisher
ISSN
Access Type
Author Information
Download PDF
Subscribe to digest