Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke
Иммуномодуляция: следующая мишень экзосом, полученных из мезенхимальных стволовых клеток, в контексте ишемического инсульта
2023-03-22
SCID: 54.1/nrg6yu4w
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immunomodulationischemic strokemesenchymal stem cell-derived exosomesneurofunctional recoverypost-stroke inflammation
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Abstract (AI)
modulation of the immune response is an additional treatment option for IS. Intriguingly, MSC-Exos mediates the inflammatory immune response following IS by modulating the central nervous system, the peripheral immune system, and immunomodulatory molecules, thereby promoting neurofunctional recovery after stroke. Thus, this paper reviews the role, potential mechanisms, and therapeutic potential of MSC-Exos in post-IS inflammation in order to identify new research targets.
Key Findings
1
Immunomodulation is identified as a promising additional therapeutic strategy for ischemic stroke.
2
MSC-derived exosome-mediated immune regulation is associated with improved neurofunctional recovery after ischemic stroke.
3
Mesenchymal stem cell-derived exosomes modulate post-stroke inflammatory immune responses through effects on the central nervous system, peripheral immune system, and immunomodulatory molecules.
4
The review summarizes proposed mechanisms and therapeutic potential of MSC-derived exosomes, highlighting immunomodulation as a target for future research.
Research Object
mesenchymal stem cell-derived exosomes in the context of ischemic stroke
Research Subject
their immunomodulatory effects and mechanisms in post-stroke inflammation, including modulation of central and peripheral immune responses and promotion of neurofunctional recovery
Publication Details
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2023-03-22
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