Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies
Метаболиты грибов, выделенных из морских осадков: современные тенденции исследований биологической активности
2021-02-04
SCID: 54.1/pwj7g5zg
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antibacterial activityanticancer agentscytoprotective activitymarine sediment-derived fungisecondary metabolites
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Abstract (AI)
Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020.
Key Findings
1
Fungi are less abundant than bacteria and archaea in marine sediments and engage in competitive relationships, influencing metabolite diversity.
2
Historically, studies focused on antibacterial and antifungal activities of these metabolites, but recent research (2016–2020) expanded to anticancer and cytoprotective drug candidate investigations.
3
Marine sediment-derived fungi produce a wide variety of low-molecular-weight secondary metabolites driven by environmental adaptation and interspecies interactions.
4
The review synthesizes research on biological activities of secondary metabolites from marine sediment-derived fungi reported between January 2016 and November 2020.
Research Object
Low-molecular-weight secondary metabolites of marine sediment-derived fungi
Research Subject
Biological activities of these metabolites (antibacterial, antifungal, anticancer, cytoprotective and related bioactivities) as reported in studies from Jan 2016 to Nov 2020
Publication Details
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2021-02-04
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