Taurine deficiency as a driver of aging
Дефицит таурина как фактор старения
2023-06-08
SCID: 54.1/qtsrnth8
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cellular senescence reductionhealth span and life span extensioninflammaging attenuationtaurine deficiencytaurine supplementation
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Abstract (AI)
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Key Findings
1
Acute endurance exercise increases taurine concentrations in humans.
2
Circulating taurine concentrations decline with aging in mice, monkeys, and humans.
3
Lower taurine concentrations in humans correlate with several age-related diseases.
4
Mechanistically, taurine reduces cellular senescence and protects against telomerase deficiency.
5
Reversal of taurine deficiency increases health span in worms, rodents, and primates, and life span in worms and rodents.
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Taurine supplementation increases health span in monkeys.
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Taurine supplementation reverses age-related taurine decline and increases health span and life span in mice.
8
Taurine suppresses mitochondrial dysfunction, decreases DNA damage, and attenuates inflammaging.
9
The findings support that taurine deficiency may be a driver of aging and justify human clinical trials to test this hypothesis.
Research Object
Circulating taurine levels in animals and humans
Research Subject
Role of taurine deficiency in driving aging and age-related decline, and the effects of taurine supplementation on health span, life span, cellular senescence, telomerase deficiency, mitochondrial dysfunction, DNA damage, and inflammaging
Publication Details
Publication Date
2023-06-08
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