Novel, Efficient, and Green Procedure for the Knoevenagel Condensation Catalyzed by Diammonium Hydrogen Phosphate in Water
Новая, эффективная и экологичная методика конденсации Кнёвенагеля, катализируемой гидрофосфатом диаммония в воде
2006-08-01
SCID: 54.1/rwh4gnz5
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Active methylene compoundsAqueous catalysisDiammonium hydrogen phosphateGreen chemistryKnoevenagel condensation
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Abstract (AI)
Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammonium hydrogen phosphate. The reactions were carried out at room temperature in short periods with very simple workup procedure and good to high yields.
Key Findings
1
Diammonium hydrogen phosphate efficiently catalyzes Knoevenagel condensation in water at a low loading of 4 mol%.
2
The condensations proceed at room temperature within short reaction times and provide good to high yields.
3
The method uses stirring in water and offers a very simple workup, supporting its efficiency and greener processing profile.
4
Various aromatic and heteroaromatic aldehydes react with methyl or ethyl cyanoacetate, malononitrile, and cyanoacetamide under the procedure.
Research Object
Knoevenagel condensation of aromatic and heteroaromatic aldehydes with active methylene compounds in water
Research Subject
Efficiency and green performance of diammonium hydrogen phosphate catalysis, including reaction rate, mild conditions, workup simplicity, and product yield
Publication Details
Publication Date
2006-08-01
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