Construction and Aromatization of Hantzsch 1,4‐Dihydropyridines under Microwave Irradiation: A Green Approach
Синтез и ароматизация 1,4-дигидропиридинов Ганча в условиях микроволнового облучения: экологичный подход
2022-01-21
SCID: 54.1/s4aqhpez
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Hantzsch 1,4-dihydropyridinesaromatizationgreen synthesismicrowave irradiationmulticomponent reaction
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Abstract (AI)
Abstract Hantzsch reaction, leading to the synthesis of 1,4‐dihydropyridines (1,4‐DHPs) with momentous biological activities and pharmacological properties is a well‐known MCR. In recent years, microwave irradiation (MWI) has been successfully used as the unconventional and green source of energy to promote organic transformations including Hantzsch 1,4‐dihydropyridines. Literature survey disclosed that construction of 1,4‐DHPs as well as their aromatization can be successfully performed under MWI in solution as well as in dry media. In this review, we try to underscore recent advances in the synthesis and aromatization of Hantzsch 1,4‐DHPs under MWI as green approach.
Key Findings
1
Both construction and aromatization of Hantzsch 1,4-dihydropyridines can be performed successfully under microwave irradiation.
2
Microwave irradiation enables green synthesis of Hantzsch 1,4-dihydropyridines, compounds with important biological and pharmacological properties.
3
Microwave-assisted Hantzsch transformations are applicable in solution and dry media.
4
The review summarizes recent advances in microwave-mediated synthesis and aromatization of Hantzsch 1,4-dihydropyridines.
Research Object
Hantzsch 1,4-dihydropyridines and their aromatization under microwave irradiation
Research Subject
Green microwave-assisted methods for constructing and aromatizing Hantzsch 1,4-dihydropyridines in solution and dry media
Publication Details
Publication Date
2022-01-21
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