Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma

Применение нового радиосенсибилизатора на основе нанобиотехнологий в лечении глиомы
Yandong Xie, Yuhan Han, Xuefeng Zhang, Hongwei Ma, Linfeng Li, Rutong Yu, Hongmei Liu
2021-03-22

blood-brain barriergliomanano-radiosensitizersnanotechnologyradiotherapy
Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. As we all know, surgical resection, chemotherapy, and radiotherapy are the main treatment methods for glioma. With the development of clinical trials and traditional treatment techniques, radiotherapy for glioma has increasingly exposed defects in the treatment effect. In order to improve the bottleneck of radiotherapy for glioma, people have done a lot of work; among this, nano-radiosensitizers have offered a novel and potential treatment method. Compared with conventional radiotherapy, nanotechnology can overcome the blood-brain barrier and improve the sensitivity of glioma to radiotherapy. This paper focuses on the research progress of nano-radiosensitizers in radiotherapy for glioma.
1
Conventional glioma radiotherapy has shown shortcomings in treatment effectiveness despite advances in clinical trials and established treatment techniques.
2
Glioma treatment remains clinically challenging because its specific pathogenesis is unclear and its therapeutic window is limited.
3
Nano-radiosensitizers represent a novel and potentially effective strategy for improving radiotherapy outcomes in glioma.
4
Nanotechnology may enhance glioma radiosensitivity and overcome the blood-brain barrier, addressing major limitations of conventional radiotherapy.
5
The paper reviews research progress on nano-radiosensitizers applied to glioma radiotherapy.

glioma treated with radiotherapy

the research progress and therapeutic radiosensitization effects of nano-radiosensitizers, including blood–brain barrier penetration and improved glioma sensitivity to radiotherapy

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2021-03-22
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Authors
Yandong Xie
Yuhan Han
Xuefeng Zhang
Hongwei Ma
Linfeng Li
Rutong Yu
Hongmei Liu
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