Correlates of vaccine-induced protection: methods and implications
Корреляты индуцированной вакцинацией защиты: методы и значение
2016-01-01
SCID: 54.1/ug89wn56
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immune correlates of protectionmaternal immunitypassive protectionvaccine efficacyvaccine-induced protection
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Abstract (AI)
The document presents an overview of definitions and methods in the area of immune correlates of vaccine-induced protection. This subject has far-reaching implications for the evaluation of vaccine efficacy, for passive protection, e.g. maternal immunity and risk screening, e.g. tuberculin testing or rubella antibody testing of pregnant women, as well as for basic understanding of pathogenesis and immunity.
Key Findings
1
Correlates of protection have implications for assessing passive immunity, including maternal protection.
2
Immune correlates are important for evaluating vaccine efficacy beyond direct clinical outcome measurements.
3
Immune correlates support risk screening applications, including tuberculin testing and rubella antibody testing in pregnant women.
4
Studying immune correlates advances understanding of disease pathogenesis and protective immunity.
5
The document reviews definitions and methodological approaches for identifying immune correlates of vaccine-induced protection.
Research Object
immune correlates of vaccine-induced protection
Research Subject
definitions, methodological approaches, and implications for evaluating vaccine efficacy, passive protection, risk screening, and the understanding of pathogenesis and immunity
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2016-01-01
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