Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine

Революция в доставке лекарственных средств: влияние передовых достижений материаловедения и технологий на прецизионную медицину
Mohamed El‐Tanani, Shakta Mani Satyam, Syed Arman Rabbani, Yahia El‐Tanani, Alaa A. A. Aljabali, Ibrahim Al Faouri, Abdul Rehman
2025-03-15

bioresponsive polymersmicrofluidicsnanocarrierspersonalized medicineprecision drug delivery
Recent progress in material science has led to the development of new drug delivery systems that go beyond the conventional approaches and offer greater accuracy and convenience in the application of therapeutic agents. This review discusses the evolutionary role of nanocarriers, hydrogels, and bioresponsive polymers that offer enhanced drug release, target accuracy, and bioavailability. Oncology, chronic disease management, and vaccine delivery are some of the applications explored in this paper to show how these materials improve the therapeutic results, counteract multidrug resistance, and allow for sustained and localized treatments. The review also discusses the translational barriers of bringing advanced materials into the clinical setting, which include issues of biocompatibility, scalability, and regulatory approval. Methods to overcome these challenges include surface modifications to reduce immunogenicity, scalable production methods such as microfluidics, and the harmonization of regulatory systems. In addition, the convergence of artificial intelligence (AI) and machine learning (ML) is opening new frontiers in material science and personalized medicine. These technologies allow for predictive modeling and real-time adjustments to optimize drug delivery to the needs of individual patients. The use of advanced materials can also be applied to rare and underserved diseases; thus, new strategies in gene therapy, orphan drugs development, and global vaccine distribution may offer new hopes for millions of patients.
1
Advanced drug-delivery materials, including nanocarriers, hydrogels, and bioresponsive polymers, improve release control, targeting accuracy, and drug bioavailability.
2
Artificial intelligence and machine learning enable predictive modeling and real-time personalization of drug delivery, including applications for rare diseases, gene therapy, orphan drugs, and global vaccine distribution.
3
Clinical translation remains limited by biocompatibility, manufacturing scalability, and regulatory-approval challenges.
4
Surface modification, scalable microfluidic production, and regulatory harmonization are identified as strategies to address translational barriers.
5
These materials support oncology, chronic-disease management, and vaccine delivery through sustained and localized treatment while potentially counteracting multidrug resistance.

advanced-material drug delivery systems, including nanocarriers, hydrogels, and bioresponsive polymers

their precision, target accuracy, drug-release control, bioavailability, therapeutic effectiveness, and clinical translation barriers

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2025-03-15
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Authors
Mohamed El‐Tanani
Shakta Mani Satyam
Syed Arman Rabbani
Yahia El‐Tanani
Alaa A. A. Aljabali
Ibrahim Al Faouri
Abdul Rehman
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