Synthesis and Characterization of 2 methylindolizino[1,2 b]quinolin 9(11H) one

Camptothecin is a natural quinoline alkaloid, initially extracted from the bark of the Chinese tree Camptotheca acuminata, which acts as a powerful anti-cancer agent by inhibiting DNA topoisomerase I. Number of Camptothecin analogs synthesized by researchers to find potent anticancer drug. Camptothecin drug having Quinoline and 2-pyrodone moiety in their structure have biological activity and their derivatives are used in number of drugs. In present work a Tetracyclic (ABCD) ring core of camptothecin was synthesized by simple method using simple starting material like aniline derivatives and 2-pyridone in six steps. The intermediates were confirmed and characterized by FT-IR, LC-MS and 1HNMR.