A mathematical model of circadian rhythms and dopamine
Математическая модель циркадных ритмов и дофамина
2021-02-17
SCID: 54.1/umtwpa3p
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REV-ERB ROR BMAL1-CLOCK interactionscircadian oscillations in dopaminergic variablescircadian rhythmsdopamine systemmathematical model
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Abstract (AI)
The predictions of the mathematical model are consistent with a wide variety of experimental observations. Our calculations show that the mechanisms proposed by experimentalists by which REV-ERB, ROR, and BMAL1-CLOCK influence the DA system are sufficient to explain the circadian oscillations observed in dopaminergic variables. Our mathematical model can be used for further investigations of the effects of the mammalian circadian clock on the dopaminergic system. The model can also be used to predict how perturbations in the circadian clock disrupt the dopaminergic system and could potentially be used to find drug targets that ameliorate these disruptions.
Key Findings
1
A mathematical model links the mammalian circadian clock to the dopaminergic (DA) system via REV-ERB, ROR, and BMAL1-CLOCK mechanisms.
2
Model predictions are consistent with a wide variety of experimental observations of dopaminergic variables.
3
The model can be used to investigate effects of the circadian clock on the dopaminergic system and predict disruption outcomes.
4
The model could potentially identify drug targets to ameliorate dopaminergic disruptions caused by circadian clock perturbations.
5
The proposed mechanisms (REV-ERB, ROR, BMAL1-CLOCK) are sufficient to explain circadian oscillations in dopaminergic variables.
Research Object
Mathematical model of the mammalian circadian clock interaction with the dopaminergic (DA) system
Research Subject
How REV-ERB, ROR, and BMAL1-CLOCK mechanisms drive circadian oscillations in dopaminergic variables and how perturbations of the circadian clock affect the dopaminergic system (including potential targets to ameliorate disruptions)
Publication Details
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2021-02-17
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