Synthesis and Pharmacokinetics of Nanosized NH2‑UiO‑66 (Zr) Metal-Organic Frameworks

Abstract The application of porous nanomaterials in drug delivery offers a promising strategy to mitigate the adverse side effects of chemotherapy. In this study, we report the synthesis of nanosized NH 2 -UiO-66 (Zr) metal-organic frameworks as carriers of doxorubicin. The nanoparticles exhibited high crystallinity with an average size of 44 nm. Surface functionalization with polyethylene glycol (PEG) markedly enhanced their colloidal stability under physiological conditions. Coated NH 2 -UiO-66 (Zr)@PEG particles demonstrated prolonged circulation in the bloodstream and a significant reduction of nonspecific accumulation in organs with high vascularization. Importantly, these particles retained their capacity for doxorubicin loading, highlighting their potential for drug delivery.