Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Двухкомпонентная наночастичная вакцина на основе спайкового белка защищает макак от инфекции SARS-CoV-2
Bart L. Haagmans, Neil P. King, Andrew B. Ward, Rogier W. Sanders, Marit J. van Gils, Kwinten Sliepen, Hannah L. Turner, Max Crispin, Judith A. Burger, Yoann Aldon, Roger Le Grand, Rashmi Ravichandran, Philip J. M. Brouwer, Ilja Bontjer, Joel D. Allen, Virginie Chesnais, Nathalie Dereuddre‐Bosquet, Sylvie van der Werf, Mitch Brinkkemper, Pauline Maisonnasse, Marloes Grobben, Mathieu Claireaux, Marlon de Gast, Romain Marlin, Ségolène Diry, Yasunori Watanabe, Julia M. Giezen, Gius Kerster, Karlijn van der Straten, Cynthia A. van der Linden, Thibaut Naninck, Meliawati Poniman, Anna Z. Mykytyn, Nisreen M.A. Okba, Edith E. Schermer, Mariëlle J. van Breemen, Tom G. Caniels, Jelle van Schooten, Nidhal Kahlaoui, Vanessa Contreras, Julien Lemaître, Catherine Chapon, Raphaël Ho Tsong Fang, Julien Villaudy, Yme U. van der Velden, Godelieve J. de Bree, Eric Ginoux
2021-01-25
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SARS-CoV-2 spike proteincynomolgus macaquesneutralizing antibody responsesprotein-based nanoparticle vaccineviral infection and replication
Abstract (AI)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
Key Findings
1
A two-component protein-based nanoparticle vaccine displays multiple copies of the SARS-CoV-2 spike protein.
2
The nanoparticle vaccine is identified as a promising candidate for limiting SARS-CoV-2 transmission and disease.
3
The vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques.
4
Vaccination protects cynomolgus macaques against high-dose SARS-CoV-2 challenge.
5
Vaccine-induced immunity strongly reduces viral infection and replication in both upper and lower airways of macaques.
Research Object

The two-component protein-based nanoparticle vaccine displaying multiple copies of the SARS-CoV-2 spike protein

Research Subject

Its immunogenicity and protective efficacy against SARS-CoV-2 infection and replication in the airways of cynomolgus macaques

Publication Details
Publication Date
2021-01-25
Journal
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ISSN
Cited by
213
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Author Information
Authors
Bart L. Haagmans
Neil P. King
Andrew B. Ward
Rogier W. Sanders
Marit J. van Gils
Kwinten Sliepen
Hannah L. Turner
Max Crispin
Judith A. Burger
Yoann Aldon
Roger Le Grand
Rashmi Ravichandran
Philip J. M. Brouwer
Ilja Bontjer
Joel D. Allen
Virginie Chesnais
Nathalie Dereuddre‐Bosquet
Sylvie van der Werf
Mitch Brinkkemper
Pauline Maisonnasse
Marloes Grobben
Mathieu Claireaux
Marlon de Gast
Romain Marlin
Ségolène Diry
Yasunori Watanabe
Julia M. Giezen
Gius Kerster
Karlijn van der Straten
Cynthia A. van der Linden
Thibaut Naninck
Meliawati Poniman
Anna Z. Mykytyn
Nisreen M.A. Okba
Edith E. Schermer
Mariëlle J. van Breemen
Tom G. Caniels
Jelle van Schooten
Nidhal Kahlaoui
Vanessa Contreras
Julien Lemaître
Catherine Chapon
Raphaël Ho Tsong Fang
Julien Villaudy
Yme U. van der Velden
Godelieve J. de Bree
Eric Ginoux
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