Assessment Practice of Patient-Centered Outcomes in Surgical Neuro-Oncology: Survey-Based Recommendations for Clinical Routine

Практика оценки исходов, ориентированных на пациента, в хирургической нейроонкологии: рекомендации для клинической практики на основе анкетного опроса
Carolin Weiß Lucas, Mirjam Renovanz, Johanna Jost, Michael Sabel, Dorothee Wiewrodt, Marion Rapp
2021-08-11

health-related quality of lifeneurocognitive assessmentpatient-reported outcomesquality assurancesurgical neuro-oncology
The psycho-oncological burden related to the diagnosis of an intracranial tumor is often accompanied by neurocognitive deficits and changes in character, overall affecting health-related quality of life (HRQoL) and activities of daily living. Regular administration of adequate screening tools is crucial to ensure a timely detection of needs for support and/or specific interventions. Although efforts have been made to assure the quality of neuro-oncological care, clinical assessment practice of patient-reported outcomes (PROs) remains overall heterogeneous, calling for a concise recommendation tailored to neuro-oncological patients. Therefore, this survey, promoted by the German Society of Neurosurgery, was conducted to evaluate thestatus quoof health care resources and PRO/neurocognition assessment practices throughout departments of surgical neuro-oncology in Germany. 72/127 (57%) of registered departments participated in the study, including 83% of all university hospital units. A second aim was to shed light on the impact of quality assurance strategies (i.e., department certification as part of an integrative neuro-oncology cancer center; CNOC) on the assessment practice, controlled for interacting structural factors, i.e., university hospital status (UH) and caseload. Despite an overall good to excellent availability of relevant health care structures (psycho-oncologist: 90%, palliative care unit: 97%, neuropsychology: 75%), a small majority of departments practice patient-centered screenings (psycho-oncological burden: 64%, HRQoL: 76%, neurocognition: 58%), however, much less frequently outside the framework of clinical trials. In this context, CNOC affiliation, representing a specific health care quality assurance process, was associated with significantly stronger PRO assessment practices regarding psycho-oncological burden, independent of UH status (common odds ratio=5.0, p=0.03). Nevertheless, PRO/neurocognitive assessment practice was not consistent even across CNOC. The overall most commonly used PRO/neurocognitive assessment tools were the Distress Thermometer (for psycho-oncological burden; 64%), the EORTC QLQ-C30 combined with the EORTC QLQ-BN20 (for HRQoL; 52%) and the Mini-Mental Status Test (for neurocognition; 67%), followed by the Montreal Cognitive Assessment (MoCA; 33%). Accordingly, for routine clinical screening, the authors recommend the Distress Thermometer and the EORTC QLQ-C30 and QLQ-BN20, complemented by the MoCA as a comparatively sensitive yet basic neurocognitive test. This recommendation is intended to encourage more regular, adequate, and standardized routine assessments in neuro-oncological practice.
1
A German survey found heterogeneous patient-reported outcome and neurocognitive assessment practices across surgical neuro-oncology departments.
2
Among 72 participating departments, relevant support structures were widely available, including psycho-oncology services (90%), palliative care units (97%), and neuropsychology (75%).
3
Certification within an integrative neuro-oncology cancer center was associated with stronger psycho-oncological outcome assessment, independent of university hospital status (common odds ratio=5.0, p=0.03).
4
Despite available resources and quality-assurance initiatives, patient-centered outcome and neurocognitive assessments remained inconsistent, supporting the need for concise neuro-oncology-specific recommendations.
5
Only modest majorities routinely screened for psycho-oncological burden (64%), health-related quality of life (76%), and neurocognition (58%), with assessments less frequent outside clinical trials.

Patient-reported outcome and neurocognitive assessment practices in surgical neuro-oncology departments in Germany

Availability, frequency, consistency, and quality-assurance-related variation of patient-centered screening for psycho-oncological burden, health-related quality of life, and neurocognition

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2021-08-11
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Carolin Weiß Lucas
Mirjam Renovanz
Johanna Jost
Michael Sabel
Dorothee Wiewrodt
Marion Rapp
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