Mobile Microrobots for Active Therapeutic Delivery

Мобильные микророботы для активной доставки терапевтических средств
Pelin Erkoc, Immihan Ceren Yasa, Hakan Ceylan, Öncay Yaşa, Yunus Alapan, Metin Sitti
2018-10-10

biohybrid microrobotscontrolled cargo releasemedical cargo loadingmobile microrobotstherapeutic delivery
Abstract Recent advances in the versatility and sophistication of design, fabrication, and control methods of mobile microrobots could have a transforming impact on future healthcare technologies. Self‐propelled or remotely actuated, synthetic, or biohybrid microrobots can navigate to difficult‐to‐reach regions in the human body to deliver therapeutics for microscopically localized medical interventions. Here, recent progress in the design of microrobotic systems concerning therapeutic delivery of drugs, cells, and genetic materials is reported. This perspective prioritizes the design aspects of microrobots for medical cargo loading, navigation in biologically relevant environments, and controlled cargo release. In the final section, future prospects and a discussion on the critical shortcomings for the benchside‐to‐bedside translation of medical microrobots are provided.
1
Advances in microrobot design, fabrication, and control enable self-propelled or remotely actuated systems for targeted therapeutic delivery.
2
Key design considerations include medical cargo loading, navigation through biologically relevant environments, and controlled cargo release.
3
Recent systems deliver diverse therapeutic cargos, including drugs, cells, and genetic materials.
4
Synthetic and biohybrid microrobots can navigate difficult-to-reach regions of the body, supporting microscopically localized medical interventions.
5
Translation from laboratory demonstrations to clinical use remains limited by critical unresolved benchside-to-bedside challenges.

mobile microrobots for therapeutic delivery in the human body

microrobot design and performance for medical cargo loading, navigation in biologically relevant environments, and controlled release of drugs, cells, and genetic materials

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2018-10-10
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Authors
Pelin Erkoc
Immihan Ceren Yasa
Hakan Ceylan
Öncay Yaşa
Yunus Alapan
Metin Sitti
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