Nanocarriers: A Reliable Tool for the Delivery of Anticancer Drugs

Нанокаррьеры: надёжный инструмент доставки противораковых препаратов
Hussein Sabit, Mohamed Abdel-Hakeem, Tahsin Shoala, Shaimaa Abdel-Ghany, Mokhtar Mamdouh Abdel-Latif, Jawaher Almulhim, Mohamed Mansy
2022-07-28

anticancer drug deliverynanomedicine translationnanoparticle imaging agentspolymeric nanoparticlestargeted nanoparticles
Nanomedicines have gained popularity due to their potential therapeutic applications, especially cancer treatment. Targeted nanoparticles can deliver drugs directly to cancer cells and enable prolonged drug release, reducing off-target toxicity and increasing therapeutic efficacy. However, translating nanomedicines from preclinical to clinical settings has been difficult. Rapid advancements in nanotechnology promise to enhance cancer therapies. Nanomedicine offers advanced targeting and multifunctionality. Nanoparticles (NPs) have several uses nowadays. They have been studied as drug transporters, tumor gene delivery agents, and imaging contrast agents. Nanomaterials based on organic, inorganic, lipid, or glycan substances and synthetic polymers have been used to enhance cancer therapies. This review focuses on polymeric nanoparticle delivery strategies for anticancer nanomedicines.
1
A variety of nanomaterials—organic, inorganic, lipid, glycan-based, and synthetic polymers—have been employed to enhance cancer treatments.
2
Nanomedicines increase therapeutic efficacy through advanced targeting and multifunctionality compared to conventional delivery.
3
Nanoparticles serve multiple roles: drug carriers, tumor gene delivery agents, and imaging contrast agents in cancer therapy.
4
Targeted nanoparticles can deliver anticancer drugs directly to cancer cells, enabling prolonged drug release and reduced off-target toxicity.
5
This review specifically emphasizes polymeric nanoparticle delivery strategies for anticancer nanomedicines.
6
Translation of nanomedicines from preclinical research to clinical application remains difficult despite promising preclinical potential.

Polymeric nanoparticle delivery systems for anticancer nanomedicines

Strategies and performance of polymeric nanoparticles as drug delivery carriers for anticancer therapies, including targeted delivery, prolonged release, reduced off-target toxicity, and multifunctionality

Publication Details
Publication Date
2022-07-28
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Authors
Hussein Sabit
Mohamed Abdel-Hakeem
Tahsin Shoala
Shaimaa Abdel-Ghany
Mokhtar Mamdouh Abdel-Latif
Jawaher Almulhim
Mohamed Mansy
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