NCCN consensuscancer patientsclinical trialsevidence-based recommendationspalliative care
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Abstract (AI)
Category 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there is uniform NCCN consensus. Category 2A: The recommendation is based on lowerlevel evidence and there is uniform NCCN consensus. Category 2B: The recommendation is based on lowerlevel evidence and there is nonuniform NCCN consensus (but no major disagreement). Category 3: The recommendation is based on any level of evidence but reflects major disagreement. All recommendations are category 2A unless otherwise noted. Clinical trials: The NCCN believes that the best management for any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged.
Key Findings
1
Category 1 recommendations require high-level evidence, such as randomized controlled trials, and uniform NCCN consensus.
2
Category 2A recommendations rely on lower-level evidence but have uniform NCCN consensus; these represent the default category unless otherwise specified.
3
Category 2B recommendations reflect lower-level evidence and nonuniform NCCN consensus without major disagreement.
4
Category 3 recommendations may be based on any evidence level but involve major disagreement; clinical trial participation is especially encouraged for cancer patients.
5
The guideline categorizes recommendations by evidence strength and degree of NCCN consensus, ranging from Category 1 to Category 3.
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2009-04-01
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