Organometallic Anticancer Compounds

Металлоорганические противораковые соединения
Ingo Ott, Nils Metzler‐Nolte, Gilles Gasser
2010-11-15

anticancer compoundsbioinorganic chemistrymedicinal chemistryorganometallic compounds
ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTOrganometallic Anticancer CompoundsGilles Gasser*†§, Ingo Ott*‡, and Nils Metzler-Nolte*§View Author Information† Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland‡ Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany§ Chair of Inorganic Chemistry I, Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44801 Bochum, Germany*To whom correspondence should be addressed. For G.G.: phone, +41(0)44 635-4611; fax, +41(0)44 635-6803; e-mail, [email protected]; Web page, www.gassergroup.com. For I.O.: phone, +49 (0)531-391 2743; fax, +49 (0)531-391 8456; e-mail, [email protected]; Web page, www.pharmchem.tu-bs.de/forschung/ott/. For N.M.-N.: phone, +49 (0)234-32 28152; fax, +49 (0)234-32 14378; e-mail, [email protected]; Web page, www.chemie.rub.de/ac1.Cite this: J. Med. Chem. 2011, 54, 1, 3–25Publication Date (Web):November 15, 2010Publication History Received8 January 2010Published online15 November 2010Published inissue 13 January 2011https://doi.org/10.1021/jm100020wCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views34024Altmetric-Citations1313LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-AlertscloseSUBJECTS:Genetics,Ligands,Metals,Reaction products,Sandwich compounds Get e-Alerts
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It surveys how incorporating metal–carbon bonds can generate anticancer compounds with properties distinct from conventional inorganic metal complexes and organic drugs.
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The article discusses diverse organometallic scaffolds and their proposed biological mechanisms, including interactions with cellular targets relevant to cancer therapy.
3
The perspective evaluates organometallic anticancer compounds as alternatives or complements to established platinum-based treatments.
4
The perspective reviews organometallic compounds investigated as anticancer agents, highlighting their medicinal chemistry and bioinorganic applications.
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The review identifies opportunities and challenges in developing organometallic compounds for medicinal use, including relationships between chemical structure, biological activity, and therapeutic potential.

organometallic anticancer compounds

their anticancer activities, mechanisms of action, and therapeutic potential

Publication Details
Publication Date
2010-11-15
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Authors
Ingo Ott
Nils Metzler‐Nolte
Gilles Gasser
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