Role of Polyethylene Glycol in the Treatment of Functional Constipation in Children
Роль полиэтиленгликоля в лечении функциональных запоров у детей
2017-08-02
SCID: 54.1/ymdnfccr
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ChildrenFunctional constipationOsmotic laxativePolyethylene glycol (PEG)Serum electrolyte monitoring
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Abstract (AI)
According to international guidelines, polyethylene glycol (PEG) is the laxative of first choice in the treatment of functional constipation in children, both for disimpaction and for maintenance treatment. PEG acts as an osmotic laxative and its efficacy is dose dependent. PEG is highly effective, has a good safety profile, and is well tolerated by children. Only minor adverse events have been reported. Overall the use of PEG in children has been reported to be safe, although in patients predisposed to water and electrolyte imbalances monitoring of serum electrolytes should be considered.
Key Findings
1
Although generally safe, serum electrolyte monitoring should be considered in children predisposed to water or electrolyte imbalances.
2
International guidelines recommend polyethylene glycol (PEG) as the first-choice laxative for children with functional constipation.
3
PEG acts as an osmotic laxative, and its therapeutic efficacy is dose dependent.
4
PEG is highly effective, well tolerated, and associated mainly with minor adverse events in children.
5
PEG is used for both fecal disimpaction and maintenance treatment in pediatric functional constipation.
Research Object
polyethylene glycol (PEG) treatment in children with functional constipation
Research Subject
PEG’s efficacy, safety, tolerability, dose dependence, and risk of water and electrolyte imbalances for disimpaction and maintenance treatment
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2017-08-02
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