The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk

// Yixin Zhang 1, 2, * , Xiaoteng Cui 3, * , Li Ning 1 and Dianjun Wei 1 1 Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China 2 School of Medical Laboratory, Tianjin Medical University, Tianjin 300070, PR China 3 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, PR China * These authors have contributed equally to this work Correspondence to: Dianjun Wei, email: weidianjun01@163.com Keywords: tumor necrosis factor-α; single nucleotide polymorphisms; sepsis; rs1800629; rs361525 Received: September 16, 2017 Accepted: November 13, 2017 Published: November 30, 2017 ABSTRACT This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α ( TNF-α ) rs1800629 and rs361525 polymorphisms on sepsis risk. We found that TNF-α rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G ( P <0.001, odds ratio (OR)=1.32), GA vs. GG ( P <0.001, OR=1.46), GA+AA vs. GG ( P <0.001, OR=1.46), and carrier A vs. carrier G ( P <0.001, OR=1.32). Subgroup analyses showed a similar result for Asian patients (all P <0.05, OR>1). TNF-α rs361525 was also associated with increased sepsis risk in Asian patients in the four genetic models (all P <0.05, OR>1). Begg’s and Egger’s tests excluded large publication bias, and sensitivity analysis indicated stable results. Our results suggest that the G/A genotype of TNF-α rs1800629 and rs361525 increases sepsis risk in an Asian population.